Zopiclone (Imovane) is indicated for the short-term therapy and symptomatic relief of insomnia characterised by problem in falling asleep, frequent nocturnal awakenings and/or early morning awakenings.
Treatment with zopiclone should usually not exceed 7-10 consecutive days. Use for more than 2-3 consecutive weeks requires full re-evaluation of the patient. Prescriptions for zopiclone must be written for short-term use (7-10 days) and it should not be prescribed in quantities exceeding a 1-month provide.
The use of hypnotics should be restricted for insomnia where disturbed sleep results in impaired daytime functioning.
Dosage and administration:
Imovane ought to solely be taken when you’ll have the ability to get a full evening’s sleep (7 to eight hours) before you have to be lively again.
The normal adult dose of zopiclone is one tablet just earlier than you go to mattress.
This medication should be taken in a single intake and never readministered during the same night.
If you’re over sixty five years of age the dose is half a pill taken just before you go to bed.
If you’ve a liver or kidney downside, the identical old really helpful dose is half a tablet taken simply before you go to bed.
Signs and symptoms:
Overdose by zopiclone tablets is usually manifested by various levels of central nervous system despair ranging from drowsiness to coma based on the quantity ingested. In delicate circumstances, symptoms embody drowsiness, confusion, and lethargy; in more severe circumstances, signs could embody ataxia, hypotonia, hypotension, methaemoglobinaemia, respiratory melancholy, and coma. Overdose should not be life threatening except combined with different CNS depressants, including alcohol. Other danger components, such as the presence of concomitant sickness and the debilitated state of the patient, could contribute to the severity of symptoms and very rarely may find yourself in fatal consequence.
In voluntary or accidental cases of zopiclone overdosage involving doses up to 340 mg, the principal results reported have been prolonged sleep, drowsiness, lethargy and ataxia.
Symptomatic and supportive treatment in enough medical surroundings is really helpful, attention ought to be paid to respiratory and cardiovascular functions. Gastric lavage or activated charcoal is just useful when performed soon after ingestion.
Hemodialysis is of no value due to the large quantity of distribution of zopiclone. Flumazenil may be a helpful antidote; nonetheless, flumazenil administration could contribute to the appearance of neurological signs (agitation, anxiousness, convulsionsand emotional lability). Intravenous fluids should be administered as wanted.